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Diseased red blood cells topple iron balance

In the inherited anemia β-thalassemia, diseased red blood cell precursors release a blood-borne signal that promotes excessive intestinal iron absorption, predisposing affected individuals to multiorgan damage (pages 1096–1101).

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Figure 1: Deregulation of hepcidin in β-thalassemia.

Katie Ris-Vicari


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Chou, S., Weiss, M. Diseased red blood cells topple iron balance. Nat Med 13, 1020–1021 (2007).

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