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Diseased red blood cells topple iron balance

Nature Medicine volume 13, pages 10201021 (2007) | Download Citation

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In the inherited anemia β-thalassemia, diseased red blood cell precursors release a blood-borne signal that promotes excessive intestinal iron absorption, predisposing affected individuals to multiorgan damage (pages 1096–1101).

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References

  1. 1.

    et al. Nat. Med. 13, 1094–1099 (2007).

  2. 2.

    & Annu. Rev. Nutr. 26, 323–342 (2006).

  3. 3.

    et al. Science 306, 2090–2093 (2004).

  4. 4.

    et al. J. Clin. Invest. 117, 1926–1932 (2007).

  5. 5.

    et al. Nat. Genet. 38, 531–539 (2006).

  6. 6.

    et al. J. Clin. Invest. 117, 1933–1939 (2007).

  7. 7.

    et al. Haematologica 91, 809–812 (2006).

  8. 8.

    et al. Blood 105, 4103–4105 (2005).

  9. 9.

    et al. Br. J. Haematol. 135, 129–138 (2006).

  10. 10.

    & Annu. Rev. Cell Dev. Biol. 21, 659–693 (2005).

  11. 11.

    et al. Circ. Res. 98, 342–350 (2006).

  12. 12.

    et al. Genes Dev. 16, 2749–2754 (2002).

  13. 13.

    & Mol. Cell 7, 949–957 (2001).

  14. 14.

    et al. J. Biol. Chem. 279, 31348–31356 (2004).

  15. 15.

    et al. Blood 97, 1968–1974 (2001).

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Author information

Affiliations

  1. Stella T. Chou and Mitchell J. Weiss are in the Division of Hematology, Children's Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, Pennsylvania 19104, USA. weissmi@email.chop.edu

    • Stella T Chou
    •  & Mitchell J Weiss

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Competing interests

The authors declare no competing financial interests.

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DOI

https://doi.org/10.1038/nm0907-1020

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