The S6K1 kinase lies downstream of a signaling network crucial for muscle hypertrophy. It now seems that S6K1 also interacts with another kinase—AMPK—to integrate muscle-cell growth with metabolic regulation.
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Nader, G. Muscle growth learns new tricks from an old dog. Nat Med 13, 1016–1018 (2007). https://doi.org/10.1038/nm0907-1016