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The clot thickens—oxidized lipids and thrombosis

Oxidized products of low-density lipoproteins (LDLs) activate platelets through CD36, demonstrating a link between deregulated lipoprotein levels, oxidative stress and thrombosis (pages 1086–1095).

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Figure 1: Role of oxidized products of LDL in promoting platelet activation and thrombus formation in vivo.

Katie Ris-Vicari

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Jackson, S., Calkin, A. The clot thickens—oxidized lipids and thrombosis. Nat Med 13, 1015–1016 (2007). https://doi.org/10.1038/nm0907-1015

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