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Modulating autoimmunity: pick your PI3 kinase

Small molecules that specifically inhibit PI3Kγ block disease in mouse models of arthritis and lupus (pages 936–943).

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Figure 1: New, selective inhibitors preferentially block GPCR-coupled activation of PI3Kγ.

Katie Ris

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Ohashi, P., Woodgett, J. Modulating autoimmunity: pick your PI3 kinase. Nat Med 11, 924–925 (2005). https://doi.org/10.1038/nm0905-924

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