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Fatal attraction: tumors beckon regulatory T cells

Tumor tissue and ascites from patients with ovarian cancer contain high levels of cells with all the hallmarks of regulatory T cells. These cells migrate into the tumor microenvironment in a process mediated by the chemokine CCL22, and are capable of suppressing antitumor responses (pages 942–949).

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Figure 1: Ovarian tumors are infiltrated by both effector (CD4+CD25) T cells and by an excess of TREG cells (CD4+CD25+).

Michael Pace


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Shevach, E. Fatal attraction: tumors beckon regulatory T cells. Nat Med 10, 900–901 (2004).

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