5-lipoxygenase, a key enzyme in the formation of proinflammatory leukotrienes, is upregulated in the macrophages of the outer layer of the aorta and promotes aneurysm formation in mice fed a high cholesterol diet. Could this point to nonsurgical prevention of aortic aneurysms (pages 966–973)?
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Supplementary Movie 1
Angiogram of an abdominal aortic aneurysm. This heavily calcified, atheromatous aneurysm is from an 80-year-old, currently asymptomatic man with a history of hypertension, diabetes mellitus, hypercholesterolemia, smoking and myocardial infarction. Video courtesy of Sotirios Tsimikas. (MPG 616 kb)
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Palinski, W. Aneurysms: leukotrienes weaken aorta from the outside. Nat Med 10, 896–898 (2004). https://doi.org/10.1038/nm0904-896
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DOI: https://doi.org/10.1038/nm0904-896
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