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Aneurysms: leukotrienes weaken aorta from the outside

5-lipoxygenase, a key enzyme in the formation of proinflammatory leukotrienes, is upregulated in the macrophages of the outer layer of the aorta and promotes aneurysm formation in mice fed a high cholesterol diet. Could this point to nonsurgical prevention of aortic aneurysms (pages 966–973)?

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Figure 1: Angiogram of an abdominal aortic aneurysm from an 80 year old, currently asymptomatic male with a history of hypertension, diabetes mellitus, hypercholesterolemia, smoking, and myocardial infarction.

Courtesy of Sotirios Tsimikas

Figure 2: Aortic remodeling and aneurysm formation.


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Supplementary Movie 1

Angiogram of an abdominal aortic aneurysm. This heavily calcified, atheromatous aneurysm is from an 80-year-old, currently asymptomatic man with a history of hypertension, diabetes mellitus, hypercholesterolemia, smoking and myocardial infarction. Video courtesy of Sotirios Tsimikas. (MPG 616 kb)

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Palinski, W. Aneurysms: leukotrienes weaken aorta from the outside. Nat Med 10, 896–898 (2004).

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