Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Aneurysms: leukotrienes weaken aorta from the outside

5-lipoxygenase, a key enzyme in the formation of proinflammatory leukotrienes, is upregulated in the macrophages of the outer layer of the aorta and promotes aneurysm formation in mice fed a high cholesterol diet. Could this point to nonsurgical prevention of aortic aneurysms (pages 966–973)?

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Angiogram of an abdominal aortic aneurysm from an 80 year old, currently asymptomatic male with a history of hypertension, diabetes mellitus, hypercholesterolemia, smoking, and myocardial infarction.

Courtesy of Sotirios Tsimikas

Figure 2: Aortic remodeling and aneurysm formation.

References

  1. The UK Small Aneurysm Trial Participants. Lancet 352, 1649–1655 (1998).

  2. Zhao, L. et al. Nat. Med. 10, 966–973 (2004).

    CAS  Article  Google Scholar 

  3. Funk, C.D. Science 294, 1871–1875 (2001).

    CAS  Article  Google Scholar 

  4. Spanbroek, R. et al. Proc. Natl. Acad. Sci. USA 100, 1238–1243 (2003).

    CAS  Article  Google Scholar 

  5. Helgadottir, A. et al. Nat. Genet. 36, 233–239 (2004).

    CAS  Article  Google Scholar 

  6. Mehrabian, M. et al. Circ. Res. 91, 120–126 (2002).

    CAS  Article  Google Scholar 

  7. Pyo, R. et al. J. Clin. Invest. 105, 1641–1649 (2000).

    CAS  Article  Google Scholar 

  8. Palinski, W. & Napoli, C. Arterioscler. Thromb. Vasc. Biol. 22, 1745–1750 (2002).

    CAS  Article  Google Scholar 

  9. Daugherty, A. & Cassis, L.A. Arterioscler. Thromb. Vasc. Biol. 24, 429–434 (2004).

    CAS  Article  Google Scholar 

  10. Hansson, G.K., Libby, P., Schönbeck, U. & Yan, Z.Q. Circ. Res. 91, 281–291 (2002).

    CAS  Article  Google Scholar 

  11. Moulton, K.S. et al. Circulation 99, 1726–1732 (1999).

    CAS  Article  Google Scholar 

  12. Palinski, W. & Tsimikas, S. J. Am. Soc. Nephrol. 13, 1673–1681 (2002).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Supplementary information

Supplementary Movie 1

Angiogram of an abdominal aortic aneurysm. This heavily calcified, atheromatous aneurysm is from an 80-year-old, currently asymptomatic man with a history of hypertension, diabetes mellitus, hypercholesterolemia, smoking and myocardial infarction. Video courtesy of Sotirios Tsimikas. (MPG 616 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Palinski, W. Aneurysms: leukotrienes weaken aorta from the outside. Nat Med 10, 896–898 (2004). https://doi.org/10.1038/nm0904-896

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0904-896

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing