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Glutamate release promotes growth of malignant gliomas

Nature Medicine volume 7, pages 10101015 (2001) | Download Citation

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Abstract

Glutamate neurotoxicity has been implicated in stroke, head trauma, multiple sclerosis and neurodegenerative diseases. Although recent data show that cultured glioma cells secrete glutamate, the growth potential of brain tumors has not yet been linked to an excitotoxic mechanism. Using bioluminescence detection of glutamate release from freshly prepared brain slices, we show that implanted glioma cells continue to secrete glutamate. Moreover, gliomas with high glutamate release have a distinct growth advantage in host brain that is not present in vitro. Treatment with the NMDA receptor antagonists MK801 or memantine slowed the growth of glutamate-secreting tumors in situ, suggesting that activation of NMDA receptors facilitates tumor expansion. These findings support a new approach for therapy of brain tumors, based upon antagonizing glutamate secretion or its target receptors.

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Acknowledgements

We thank S. Goldman for critical review of this manuscript. This study was supported by NIH/NINDS grants NS30007 and NS38073 (to M.N.).

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Affiliations

  1. Department of Cell Biology, Anatomy and Pathology, New York Medical College, Valhalla, New York, USA

    • Takahiro Takano
    • , Jane H.-C. Lin
    • , Gregory Arcuino
    • , Qun Gao
    •  & Maiken Nedergaard
  2. Department of Anesthesiology, University of Rochester Medical Center, Rochester, New York, USA

    • Jay Yang

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Correspondence to Maiken Nedergaard.

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https://doi.org/10.1038/nm0901-1010

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