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Combinations for cancer prevention

Nature Medicine volume 6, pages 974–975 (2000)Cite this article

Combination therapies involving inhibitors of the epidermal growth factor and cyclooxygenase signaling prevent colorectal adenomas in mice. This synergistic effect may be due to the convergance of these two signaling pathways (pages 1024–1028).

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Figure 1: Interactions between the epidermal growth factor receptor (EGFR) and Cyclooxygenase (COX) pathways.

References

  1. Torrance, et al. Combinatorial chemoprevention of intestinal neoplasia using an NSAID and an EGFR-kinase inhibitor. Nature Med. 6, 1024 –1028 (2000).

    Article  CAS  Google Scholar 

  2. Steinbach, G. et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N. Engl. J. Med. 342 , 1946–1952 (2000).

    Article  CAS  Google Scholar 

  3. Pegram, M. et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J. Clin. Oncol. 16, 2659– 2671 (1998).

    Article  CAS  Google Scholar 

  4. Kelloff, G. et al. Epidermal growth factor receptor tyrosine kinase inhibitors as potential cancer chemopreventives. Cancer Epidemiol. Biomarkers Prev. 5, 657–666 ( 1996).

    CAS  PubMed  Google Scholar 

  5. Masferrer, J.L. et al. Antiangiogenic and antitumor activities of cyclooxygenase-2 Inhibitors. Cancer Res. 60, 1306– 1311 (2000).

    CAS  PubMed  Google Scholar 

  6. Tsujii, M. et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93, 705–716 (1998).

    Article  CAS  Google Scholar 

  7. Williams, C.S., Tsujii, M., Reese, J., Dey, S.K. & DuBois, R.N. Host cyclooxygenase-2 modulates carcinoma growth. J. Clin. Invest. 105, 1589–1594 (2000).

    Article  CAS  Google Scholar 

  8. He, T.C., Chan, T.A., Vogelstein, B. & Kinzler, K.W. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs . Cell 99, 335–345 (1999).

    Article  CAS  Google Scholar 

  9. Feldman, A.M., Lorell, B.H. & Reis, S.E. Trastuzumab in the treatment of metastatic breast cancer: anticancer therapy versus cardiotoxicity. Circulation 102, 272–274 (2000).

    Article  CAS  Google Scholar 

  10. Laine, L. et al. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis. Gastroenterology 117 , 776–783 (1999).

    Article  CAS  Google Scholar 

  11. Simon, L.S. et al. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. J. Am. Med. Assoc. 282, 1921–1928 (1999).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Medicine and Cell Biology, Vanderbilt University Medical Center, The Vanderbilt-Ingram Cancer Center, Nashville Veterans Affairs Medical Center, Nashville, 37232-2279, Tennessee

    Rajnish A. Gupta & Raymond N. DuBois

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  1. Rajnish A. Gupta
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  2. Raymond N. DuBois
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Gupta, R., DuBois, R. Combinations for cancer prevention. Nat Med 6, 974–975 (2000). https://doi.org/10.1038/79664

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