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Febrile convulsions: a 'benign' condition?

Abstract

A new rodent model of hyperthermia-induced seizures (page 888) raises questions about the role of GABAergic inhibition in epilepsy.

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References

  1. VanLandingham, K.E. Heinz, E.R., Cavazos, J.E. & Lewis, D.V. Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions Ann. Neurol. 43, 413–426 (1998).

    Article  CAS  Google Scholar 

  2. Annegers, J.F., Hauser, W.A., Shirts, S.B. & Kurland, L.T. Factors prognostic of unprovoked seizures after febrile convulsions. N. Engl. J. Med. 316,493–498 (1987).

    Article  CAS  Google Scholar 

  3. Chen, K., Baram, T.Z. & Soltesz, T. Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nature Med. 5, 888–894 ( 1999).

    Article  CAS  Google Scholar 

  4. Toth, Z., Yan, X.X., Haftoglou, S., Ribak, C.E. & Baram, T.Z. Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model. J. Neurosci. 18, 4285–4294 (1998).

    Article  CAS  Google Scholar 

  5. Nusser, Z., Hajos, N., Somogyi, P. & Mody, I. Increased number of synaptic GABA(A) receptors underlies potentiation at hippocampal inhibitory synapses. Nature 395, 172– 177 (1998).

    Article  CAS  Google Scholar 

  6. Buhl, E.H., Otis, T.S. & Mody, I. Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science 271, 369–373 (1996).

    Article  CAS  Google Scholar 

  7. Brooks-Kayal, A.R., Shumate, M.D., Jin, H., Rikhter, T.Y. & Coulter, D.A. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nature Med. 4, 1166–1172 ( 1998).

    Article  CAS  Google Scholar 

  8. Prince, D.A. & Jacobs, K. Inhibitory function in two models of chronic epileptogenesis. Epilepsy Res. 32, 83–92 (1998).

    Article  CAS  Google Scholar 

  9. Huang YY. et al. A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning. Cell 79, 69–79 ( 1994).

    Article  CAS  Google Scholar 

  10. Nicoll, R.A. & Malenka, R.C. Contrasting properties of two forms of long-term potentiation in the hippocampus. Nature 377, 115–118 (1995).

    Article  CAS  Google Scholar 

  11. Chain, D.G., Hegde, A.N., Yamamoto, N., Liu-Marsh, B. & Schwartz, J.H. Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia. J. Neurosci. 15 , 7592–7603 (1995).

    Article  CAS  Google Scholar 

  12. Cobb, S.R., Buhl, E.H., Halasy, K., Paulsen, O. & Somogyi, P. Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons. Nature 378, 75–78 (1995).

    Article  CAS  Google Scholar 

  13. Fernandez, G. et al. Hippocampal malformation as a cause of familial febrile convulsions and subsequent hippocampal sclerosis. Neurology 50, 909–17 (1998).

    Article  CAS  Google Scholar 

  14. Hart, Y.M., Sander, J.W., Johnson, A.L. & Shorvon, S.D. National General Practice Study of Epilepsy: recurrence after a first seizure. Lancet 336, 1271–1274 (1990).

    Article  CAS  Google Scholar 

  15. Verity, C.M., Greenwood, R. & Golding, J. Long-term intellectual and behavioral outcomes of children with febrile convulsions. N. Engl. J. Med. 338, 1723–1728 (1998).

    Article  CAS  Google Scholar 

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Walker, M., Kullmann, D. Febrile convulsions: a 'benign' condition?. Nat Med 5, 871–872 (1999). https://doi.org/10.1038/11308

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