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Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation

Nature Medicine volume 4, pages 929–933 (1998)Cite this article

An Erratum to this article was published on 01 October 1998

Abstract

The adult heart lacks reserve cardiocytes and cannot regenerate. Therefore, a large acute myocardial infarction often develops into congestive heart failure. To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous transfer), monitored cardiac function in vivo for two to six weeks and examined serial sections of the hearts by light and electron microscopy. Islands of different sizes comprising elongated, striated cells that retained characteristics of both skeletal and cardiac cells were found in the cryoinfarct. In rabbits in which myoblasts were incorporated, myocardial performance was improved. The ability to regeneratefunctioning muscle after autologous myoblast transplantation could have a important effect on patients after acute myocardial infarction.

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Authors and Affiliations

  1. Department of Medicine, Duke University Medical Center, PO Box 3327, Durham, North Carolina, 27710, USA

    Doris A. Taylor, Kelley A. Hutcheson & William E. Kraus

  2. Department of Surgery, Duke University Medical Center, PO Box 3851, Durham, North Carolina, 27710, USA

    Doris A. Taylor, B. Zane Atkins & Donald D. Glower

  3. Department of Biomedical Engineering, Duke University Medical Center, PO Box 3327, Durham, North Carolina, 27710, USA

    Doris A. Taylor, Pinata Hungspreugs, Thomas R. Jones & Donald D. Glower

  4. Department of Cell Biology, Duke University Medical Center, PO Box 3327, Durham, North Carolina, 27710, USA

    Mary C. Reedy & William E. Kraus

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  1. Doris A. Taylor
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Taylor, D., Atkins, B., Hungspreugs, P. et al. Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation. Nat Med 4, 929–933 (1998). https://doi.org/10.1038/nm0898-929

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