The thalassemias and related genetic diseases pose public health problems for many countries in the next millennium. Will it be possible to apply research results to their control and management on the scale required?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
214,86 € per year
only 17,91 € per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Weatherall, D.J. & Clegg, J.B. The Thalassemia Syndromes (Blackwell Scientific Publ., Oxford, 1981).
Weatherall, D.J., Thalassemia. in The Molecular Basis of Blood Diseases (eds. Stamatoyannopoulos, G., Nienhuis, A.W., Majerus, P.W. & Varmus, H.) 157–206 (Saunders, Philadelphia, 1994).
Fawdry, A.L. Erythroblastic anaemia of childhood (Cooley's) anaemia in Cyprus. Lancet i, 171–176 (1944)
WHO Working Group on the Community Control of Hereditary Anaemias. Bull. World Health Organ. 61, 63–80 (1983)
Ingram, V.M. & Stretton, A.O.W. Genetic basis of the thalassaemia diseases. Nature 184, 1903–1909 (1959)
Weatherall, D.J., Clegg, J.B. & Naughton, M.A. Globin synthesis in thalassaemia: An in vitro study. Nature 208, 1061–1065 (1965).
Ottolenghi, S. et al. The severe form of α thalassaemia is caused by a haemoglobin gene deletion. Nature 251, 389–392 (1974)
Taylor, J.M. et al. Genetic lesion in homozygous α thalassaemia (hydrops fetalis). Nature 251, 392–393 (1974).
Chang, J.C. & Kan, Y.W. β thalassemia, a nonsense mutation in man. Proc. Natl. Acad. Sci. USA 76, 2886–2889 (1979).
Orkin, S.H., Old, J.M., Weatherall, D.J. & Nathan, D.G. Partial deletion of β-globin gene DNA in certain patients with β thalassemia. Proc. Natl. Acad. Sci. USA 76, 2400–2404 (1979).
Orkin, S.H. et al. Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster. Nature 296, 627–631 (1982).
Weatherall, D.J. The molecular basis for phenotypic variability of the common thalassaemias. Mol. Med. Today 1, 15–20 (1995).
Flint, J., Harding, R.M., Boyce, A.J. & Clegg, J.B. The population genetics of the haemoglobinopathies. Clin. Haematol. 6, 215–262 (1993).
Kan, Y.W., Golbus, M.S. & Dozy, A.M. Prenatal diagnosis of α-thalassemia: Clinical application of molecular hybridization. N. Engl. J. Med. 295, 1165–1167 (1976).
Kan, Y.W. & Dozy, A.M. Antenatal diagnosis of sickle cell anaemia by DNA analysis of amniotic-fluid cells. Lancet ii, 910–913 (1978).
Cao, A. & Rosatelli, M.C. Screening and prenatal diagnosis of the haemoglobinopathies. Clin. Haematol. 6, 263–286 (1993).
Wotld Development Report 1993 (Oxford Univ. Press, Oxford, 1993).
Wasi, P. et al. Alpha- and beta-thalassemia in Thailand. Ann. N. Y. Acad. Sci. 165, 60–82 (1969).
Olivieri, N.F. et al. Iron-chelation therapy with oral deferiprone in patients with thalassemia major. N. Engl. J. Med. 332, 918–922 (1995)
Olivieri, N.F. Clinical experience with reactiviation of fetal hemoglobin in the beta hemoglobinopathies. Semin. Hematol. 33, 24–42 (1995).
Craig, J.E. et al. Dissecting the loci controlling fetal haemoglobin produciton on chromosomes 11p and 6 q by the regressive approach. Nature Genet. 12, 58–63 (1996).
Tinsley, J.M. & Davies, K.E. Utrophin: A potential replacement for dystrophin? Neuromuscul. Disord. 3, 537–599 (1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Weatherall, D., Clegg, J. Thalassemia — a global public health problem. Nat Med 2, 847–849 (1996). https://doi.org/10.1038/nm0896-847
Issue Date:
DOI: https://doi.org/10.1038/nm0896-847
