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Evidence of an X-linked or recessive genetic component to prostate cancer risk

Nature Medicine volume 1, pages 827–829 (1995)Cite this article

Abstract

We used data from a population-based cohort study of blacks, Hispanics, Japanese and whites to examine the frequency of prevalent prostate and breast cancer by family history status of first-degree relatives (parents and siblings). Independent of race, the age-adjusted relative risk for prevalent prostate cancer in subjects with affected brothers was approximately two times that in subjects with affected fathers (P < 0.00005). No such excess risk for breast cancer was observed among subjects with affected sisters compared to those with affected mothers (age- and race-adjusted relative risk = 1.10, P= 0.34). The magnitude of the relative risk for prostate cancer in sibling-versus parent-affected groups was significantly different from that of the comparable relative risk for breast cancer (P < 0.00005). An excess risk of prostate cancer in men with affected brothers compared to those with affected fathers is consistent with the hypothesis of an X-linked, or recessive, model of inheritance.

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Authors and Affiliations

  1. Department of Preventive Medicine, University of Southern California School of Medicine, 1420 San Pablo Street PMB-B307, Los Angeles, California, 90033, USA

    Kristine R. Monroe, Mimi C. Yu, Ronald K. Ross & Brian E. Henderson

  2. Department of Urology, University of Southern California School of Medicine, 1420 San Pablo Street PMB-B307, Los Angeles, California, 90033, USA

    Gerhard A. Coetzee

  3. Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, 96813, USA

    Laurence N. Kolonel & Lynne R. Wilkens

Authors
  1. Kristine R. Monroe
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  2. Mimi C. Yu
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  3. Laurence N. Kolonel
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  4. Gerhard A. Coetzee
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  5. Lynne R. Wilkens
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  6. Ronald K. Ross
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  7. Brian E. Henderson
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Monroe, K., Yu, M., Kolonel, L. et al. Evidence of an X-linked or recessive genetic component to prostate cancer risk. Nat Med 1, 827–829 (1995). https://doi.org/10.1038/nm0895-827

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