Turning on the angiogenic microswitch

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The angiogenic switch, which leads to the activation of endothelial cell proliferation and the growth of new blood vessels, is a crucial step in tumorigenesis. A study now shows that this process is linked to a microRNA in endothelial cells (909–914). Blocking microRNAs may offer new avenues for antiangiogenesis therapy to treat cancer.

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Figure 1: A miR-132–dependent angiogenic microswitch can be targeted to block cancer progression and angiogenesis.

Katie Vicari

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Correspondence to Ralf H Adams.

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