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Turning on the angiogenic microswitch

Nature Medicine volume 16, pages 853–854 (2010)Cite this article

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The angiogenic switch, which leads to the activation of endothelial cell proliferation and the growth of new blood vessels, is a crucial step in tumorigenesis. A study now shows that this process is linked to a microRNA in endothelial cells (909–914). Blocking microRNAs may offer new avenues for antiangiogenesis therapy to treat cancer.

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Figure 1: A miR-132–dependent angiogenic microswitch can be targeted to block cancer progression and angiogenesis.

Katie Vicari

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Authors and Affiliations

  1. Hanna M. Eilken and Ralf H. Adams are at the Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and University of Münster, Faculty of Medicine, Münster, Germany.,

    Hanna M Eilken & Ralf H Adams

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  1. Hanna M Eilken
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  2. Ralf H Adams
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Correspondence to Ralf H Adams.

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The authors declare no competing financial interests.

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Eilken, H., Adams, R. Turning on the angiogenic microswitch. Nat Med 16, 853–854 (2010). https://doi.org/10.1038/nm0810-853

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