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Mammary development meets cancer genomics

Mammary epithelial cell development is thought to progress from undifferentiated stem cells into at least two differentiated cell types. A new study has now characterized some of these distinct developmental stages and links them to tumor subtypes previously defined by gene expression profiling (pages 907–913).

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Figure 1: Model of the human mammary epithelial hierarchy linked to cancer subtype.

Katie Vicari


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Correspondence to Charles M. Perou.

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Prat, A., Perou, C. Mammary development meets cancer genomics. Nat Med 15, 842–844 (2009).

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