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Rosacea: skin innate immunity gone awry?

Rosacea is a common skin disorder marked by chronic inflammation and vascular abnormalities. Two new features of the skin lesions have been identified: elevated levels of cathelicidin antimicrobial peptides and of a related serine protease. These molecules of innate immunity may represent key elements of pathogenesis, as well as new targets for effective therapies (pages 975–981).

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Figure 1: Rosacea and proteolytic processing of cathelicidin peptides.

Katie Ris-Vicari


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Bevins, C., Liu, FT. Rosacea: skin innate immunity gone awry?. Nat Med 13, 904–906 (2007).

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