Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The curiosity of IL-15

Mice deficient for the cytokine interleukin-15 are unexpectedly protected from sepsis. Orinska and colleagues show that interleukin-15 signals intracellularly in mast cells and limits their recruitment of neutrophils to clear the infection (pages 927–934).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Responses in wild-type and IL-15–deficient mice during sepsis.

Katie Ris-Vicari

References

  1. Angus, D.C. et al. Crit. Care Med. 29, 1303–1310 (2001).

    Article  CAS  Google Scholar 

  2. Martin, G.S., Mannino, D.M., Eaton, S. & Moss, M. N. Engl. J. Med. 348, 1546–1554 (2003).

    Article  Google Scholar 

  3. Echtenacher, B., Mannel, D.N. & Hultner, L. Nature 381, 75–77 (1996).

    Article  CAS  Google Scholar 

  4. Remick, D.G., Newcomb, D.E., Bolgos, G.L. & Call, D.R. Shock 13, 110–116 (2000).

    Article  CAS  Google Scholar 

  5. Orinska, Z. et al. Nat. Med. 13, 927–934 (2007).

    Article  CAS  Google Scholar 

  6. Ohteki, T. Curr. Mol. Med. 2, 371–380 (2002).

    Article  CAS  Google Scholar 

  7. Hiromatsu, T. et al. J. Infect. Dis. 187, 1442–1451 (2003).

    Article  CAS  Google Scholar 

  8. Mulligan, M.S., Jones, M.L., Vaporciyan, A.A., Howard, M.C. & Ward, P.A. J. Immunol. 151, 5666–5674 (1993).

    CAS  PubMed  Google Scholar 

  9. Lotze, M.T. & Tracey, K.J. Nat. Rev. Immunol. 5, 331–342 (2005).

    Article  CAS  Google Scholar 

  10. Mallen-St Clair, J., Pham, C.T., Villalta, S.A., Caughey, G.H. & Wolters, P.J. J. Clin. Invest. 113, 628–634 (2004).

    Article  CAS  Google Scholar 

  11. Kanamaru, Y. et al. J. Immunol. 174, 4193–4197 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ward, P. The curiosity of IL-15. Nat Med 13, 903–904 (2007). https://doi.org/10.1038/nm0807-903

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0807-903

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing