Side effects may include evolution

Certain antibiotics prompt Streptococcus pneumoniae to take up DNA from the environment, which may enable the microbe to acquire genes for antibiotic resistance.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Stress placed on S. pneumoniae by treatment with antibiotics causes induction of the state of competence.

Ann Thomson

References

  1. 1

    McKenzie, G.J. et al. Proc. Natl. Acad. Sci. USA. 97, 6646–6651 (2000).

  2. 2

    Cirz, R.T. et al. PLoS Biol. 3, e176 (2005).

  3. 3

    Beaber, J.W. et al. Nature 427, 72–74 (2004).

  4. 4

    Goerke, C. et al. Antimicrob. Agents Chemother. 50, 171–177 (2006).

  5. 5

    Maiques, E. et al. J. Bacteriol. 188, 2726–2729 (2006).

  6. 6

    Zhang, X. et al. J. Infect. Dis. 181, 664–670 (2000).

  7. 7

    Ubeda, C. et al. Mol. Microbiol. 56, 836–844 (2005).

  8. 8

    Prudhomme, M. et al. Science 313, 89–92 (2006).

  9. 9

    Lorenz, M.G. et al. Microbiol. Rev. 58, 563–602 (1994).

  10. 10

    Steffen, S.E. et al. Arch. Biochem. Biophys. 328, 303–309 (2000).

  11. 11

    Claverys, J.P. et al. Annu. Rev. Microbiol. 60, 451–475 (2006).

  12. 12

    Wagner, J. et al. Mol. Cell 4, 281–286 (1999).

  13. 13

    Sung, H.M. et al. J. Bacteriol. 185, 2153–2160 (2003).

  14. 14

    Munoz-Najar, U. et al. J. Bacteriol. 181, 2782–2788 (1999).

  15. 15

    Rattray, A.J. et al. Genetics 162, 1063–1077 (2002).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading