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Tyrosine kinases: maiming myelin in leprosy

Mycobacterium leprae, the bacterium that causes leprosy, causes the breakdown of myelin. This breakdown is now shown to occur through the ErbB2 receptor, a process that can be blocked by Herceptin and kinase inhibitors (pages 961966).

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Figure 1: Mycobacterium leprae, the causative agent of leprosy, activates ErbB2 receptors on the surface of myelinating Schwann cells.

Kim Caesar

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Franklin, R., Zhao, C. Tyrosine kinases: maiming myelin in leprosy. Nat Med 12, 889–890 (2006). https://doi.org/10.1038/nm0806-889

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