Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

ALS: life and death in a bad neighborhood

The role of inflammatory mechanisms in amyotrophic lateral sclerosis is a hotly debated topic. Findings in a mouse model now add weight to arguments that targeting of inflammatory cells might be a fruitful therapeutic approach.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Microglia respond to several types of immunological alarm signals.

Kim Caesar


  1. Boillee, S. et al. Science 312, 1389–1392 (2006).

    Article  CAS  Google Scholar 

  2. Haverkamp, L.J., Appel, V. & Appel, S.H. Brain 118 (Pt 3), 707–719 (1995).

    Article  Google Scholar 

  3. Rosen, D.R. et al. Nature 362, 59–62 (1993).

    Article  CAS  Google Scholar 

  4. Wilms, H. et al. J. Neuroimmunol. 144, 139–142 (2003).

    Article  CAS  Google Scholar 

  5. Troost, D., Van den Oord, J.J. & Vianney de Jong, J.M. Neuropathol. Appl. Neurobiol. 16, 401–410 (1990).

    Article  CAS  Google Scholar 

  6. Sargsyan, S.A., Monk, P.N. & Shaw, P.J. Glia 51, 241–253 (2005).

    Article  Google Scholar 

  7. McGeer, E.G. & McGeer, P.L. BioDrugs 19, 31–37 (2005).

    Article  CAS  Google Scholar 

  8. Wang, J. et al. Neurobiol. Dis. 20, 943–952 (2005).

    Article  CAS  Google Scholar 

  9. Coull, J.A. et al. Nature 438, 1017–1021 (2005).

    Article  CAS  Google Scholar 

  10. Zhao, W. et al. J. Neuropathol. Exp. Neurol. 63, 964–977 (2004).

    Article  CAS  Google Scholar 

  11. Stolzing, A. & Grune, T. FASEB J. 18, 743–745 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Monk, P., Shaw, P. ALS: life and death in a bad neighborhood. Nat Med 12, 885–887 (2006).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing