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Turning neurogenesis up a Notch

The key developmental regulator Notch was first characterized in flies but has since been implicated in diseases ranging from cancer to migraine. Experiments in a rat model now suggest that activation of Notch can also promote neurogenesis and healing after stroke.

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Figure 1: Notch ligands, acting through Notch and downstream effectors (PI3K-Akt, mTOR, STAT3, Hes3 and Shh) promote the survival of neural stem cells.


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Greenberg, D., Jin, K. Turning neurogenesis up a Notch. Nat Med 12, 884–885 (2006).

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