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Turning neurogenesis up a Notch

Nature Medicine volume 12, pages 884–885 (2006)Cite this article

The key developmental regulator Notch was first characterized in flies but has since been implicated in diseases ranging from cancer to migraine. Experiments in a rat model now suggest that activation of Notch can also promote neurogenesis and healing after stroke.

Most individuals improve to some extent in the weeks to months after a stroke, but many are left with deficits severe enough to preclude return to independent function1. One goal of neurological research is to harness the brain's innate capacity for repair to achieve better outcome in stroke and other brain diseases. One potentially useful approach is based on the observation that injury stimulates neurogenesis in the adult brain2.

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Figure 1: Notch ligands, acting through Notch and downstream effectors (PI3K-Akt, mTOR, STAT3, Hes3 and Shh) promote the survival of neural stem cells.

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  1. Buck Institute for Age Research, Novato, 94945, California, USA

    David A Greenberg & Kunlin Jin

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  1. David A Greenberg
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  2. Kunlin Jin
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Greenberg, D., Jin, K. Turning neurogenesis up a Notch. Nat Med 12, 884–885 (2006). https://doi.org/10.1038/nm0806-884

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