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Turning neurogenesis up a Notch

Nature Medicine volume 12, pages 884–885 (2006)Cite this article

The key developmental regulator Notch was first characterized in flies but has since been implicated in diseases ranging from cancer to migraine. Experiments in a rat model now suggest that activation of Notch can also promote neurogenesis and healing after stroke.

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Figure 1: Notch ligands, acting through Notch and downstream effectors (PI3K-Akt, mTOR, STAT3, Hes3 and Shh) promote the survival of neural stem cells.

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  1. Buck Institute for Age Research, Novato, 94945, California, USA

    David A Greenberg & Kunlin Jin

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  1. David A Greenberg
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  2. Kunlin Jin
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Greenberg, D., Jin, K. Turning neurogenesis up a Notch. Nat Med 12, 884–885 (2006). https://doi.org/10.1038/nm0806-884

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