Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Treating cancer's kinase 'addiction'

When the tyrosine kinase inhibitor imatinib (Gleevec) was found to induce high remission rates in patients with chronic myeloid leukemia, this was hailed as a success for targeted tumor therapy. Since then, the repertoire of cancer types that respond to such inhibitors has expanded and researchers are beginning to grapple with the problem of acquired drug resistance. The activating kinase mutations targeted by these drugs can be viewed as the Achilles heel of cancer—they promote malignant progression, yet can turn cancer into a therapeutically exploitable disease.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Tyrosine kinases targeted by imatinib.

References

  1. Hunter, T. & Eckhart, W. Cell 116, S35–S39, 1 p following S48 (2004).

    CAS  Article  Google Scholar 

  2. Gschwind, A., Fischer, O.M. & Ullrich, A. Nat. Rev. Cancer 4, 361–370 (2004).

    CAS  Article  Google Scholar 

  3. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. & Sudarsanam, S. Science 298, 1912–1934 (2002).

    CAS  Article  Google Scholar 

  4. Rowley, J.D. Nature 243, 290–293 (1973).

    CAS  Article  Google Scholar 

  5. Heisterkamp, N. et al. Nature 344, 251–253 (1990).

    CAS  Article  Google Scholar 

  6. Kelliher, M.A., McLaughlin, J., Witte, O.N. & Rosenberg, N. Proc. Natl. Acad. Sci. USA 87, 6649–6653 (1990).

    CAS  Article  Google Scholar 

  7. Daley, G.Q., Van Etten, R.A. & Baltimore, D. Science 247, 824–830 (1990).

    CAS  Article  Google Scholar 

  8. Noble, M.E., Endicott, J.A. & Johnson, L.N. Science 303, 1800–1805 (2004).

    CAS  Article  Google Scholar 

  9. Buchdunger, E. et al. Cancer Res. 56, 100–104 (1996).

    CAS  PubMed  Google Scholar 

  10. Druker, B.J. et al. Nat. Med. 2, 561–566 (1996).

    CAS  Article  Google Scholar 

  11. Druker, B.J. et al. N. Engl. J. Med. 344, 1031–1037 (2001).

    CAS  Article  Google Scholar 

  12. Druker, B.J. et al. N. Engl. J. Med. 344, 1038–1042 (2001).

    CAS  Article  Google Scholar 

  13. O'Brien, S.G. et al. N. Engl. J. Med. 348, 994–1004 (2003).

    CAS  Article  Google Scholar 

  14. Buchdunger, E. et al. J. Pharmacol. Exp. Ther. 295, 139–145 (2000).

    CAS  PubMed  Google Scholar 

  15. Buchdunger, E. et al. Proc. Natl. Acad. Sci. USA 92, 2558–2562 (1995).

    CAS  Article  Google Scholar 

  16. Joensuu, H. et al. N. Engl. J. Med. 344, 1052–1056 (2001).

    CAS  Article  Google Scholar 

  17. Heinrich, M.C. et al. J. Clin. Oncol. 21, 4342–4349 (2003).

    CAS  Article  Google Scholar 

  18. Apperley, J.F. et al. N. Engl. J. Med. 347, 481–487 (2002).

    CAS  Article  Google Scholar 

  19. Cools, J. et al. N. Engl. J. Med. 348, 1201–1214 (2003).

    CAS  Article  Google Scholar 

  20. Rubin, B.P. et al. J. Clin. Oncol. 20, 3586–3591 (2002).

    CAS  Article  Google Scholar 

  21. Gorre, M.E. et al. Science 293, 876–880 (2001).

    CAS  Article  Google Scholar 

  22. Azam, M., Latek, R.R. & Daley, G.Q. Cell 112, 831–843 (2003).

    CAS  Article  Google Scholar 

  23. Shah, N.P., Tran, C., Lee, F.Y., Chen, P., Norris, D. & Sawyers, C.L. Science 305, 399–401 (2004).

    CAS  Article  Google Scholar 

  24. Demetri, G.D. et al. Proc. Am. Soc. Clin. Oncol. 23, 195 (2004).

    Google Scholar 

  25. Mendelsohn, J. & Baselga, J. J. Clin. Oncol. 21, 2787–2799 (2003).

    CAS  Article  Google Scholar 

  26. Kaelin, W.G. Jr. Sci. STKE 2004, pe12 (2004).

    PubMed  Google Scholar 

  27. Arteaga, C.L. & Baselga, J. Cancer Cell 5, 525–531 (2004).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Baselga, J., Arribas, J. Treating cancer's kinase 'addiction'. Nat Med 10, 786–787 (2004). https://doi.org/10.1038/nm0804-786

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0804-786

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing