Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Gene delivery goes global

For gene therapy of muscular dystrophies, all of the skeletal muscles in the body must be transduced—a tough challenge. An approach that permeabilizes blood vessels using VEGF, helping low doses of a parvovirus-based gene therapy vector sneak across the vessel wall, now solves this problem in mice (pages 828–834).

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Delivery of a therapeutic gene to the skeletal muscles and heart of an adult animal with muscular dystrophy.

Paul Gregorevic


  1. Gregorevic, P. et al. Nat. Med. 10, 828–834 (2004).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. Xia, H., Mao, Q. & Davidson, B.L. Nat. Biotechnol. 19, 640–644 (2001).

    CAS  Article  PubMed  Google Scholar 

  3. Grimm, D. & Kay, M.A. Curr. Gene Ther. 3, 281–304 (2003).

    CAS  Article  PubMed  Google Scholar 

  4. Summerford, C. & Samulski, R.J. J. Virol. 72, 1438–1445 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Di Pasquale, G. et al. Nat. Med. 9, 1306–1312 (2003).

    CAS  Article  PubMed  Google Scholar 

  6. Halbert, C.L., Allen, J.M. & Miller, A.D. J. Virol. 75, 6615–6624 (2001).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. Greelish, J.P. et al. Nat. Med. 5, 439–443 (1999).

    CAS  Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Thomas, C. Gene delivery goes global. Nat Med 10, 782–783 (2004).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing