Staphylococcal protein A inflames the lungs

Staphylococcal pneumonia is associated with a huge influx of inflammatory cells into the lungs. A major trigger for this event is now revealed. Protein A, a bacterial surface protein, binds the receptor for TNFα, a prominent activator of the innate immune system (pages 842–848).

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Figure 1: Activation of TNFR1 by staphylococcal protein A initiates a signaling cascade leading to NF-κB activation and subsequently to an inflammatory response, including production of cytokines and chemokines and a heavy infiltration of PMNs from the bloodstream.

Kimberly Caesar

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Normark, B., Normark, S. & Norrby-Teglund, A. Staphylococcal protein A inflames the lungs. Nat Med 10, 780–781 (2004). https://doi.org/10.1038/nm0804-780

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