News & Views | Published:

Staphylococcal protein A inflames the lungs

Nature Medicine volume 10, pages 780781 (2004) | Download Citation

Subjects

Staphylococcal pneumonia is associated with a huge influx of inflammatory cells into the lungs. A major trigger for this event is now revealed. Protein A, a bacterial surface protein, binds the receptor for TNFα, a prominent activator of the innate immune system (pages 842–848).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Clin. Diagn. Lab. Immunol. 8, 1064–1069 (2001).

  2. 2.

    & Clin. Microbiol. Infect. 9, 1179–1186 (2003).

  3. 3.

    et al. Nat. Med. 10, 842–848 (2004).

  4. 4.

    et al. J. Immunol. 171, 6820–6826 (2003).

  5. 5.

    , & J. Exp. Med. 189, 657–662 (1999).

  6. 6.

    et al. EMBO J. 18, 9–21 (1999).

  7. 7.

    et al. Proc. Natl. Acad. Sci USA 97, 5399–5404 (2000).

  8. 8.

    , , & J. Immunol. 172, 3377–3381 (2004).

  9. 9.

    et al. Cell 116, 367–379 (2004).

  10. 10.

    , & J. Biol. Chem. published online, 15 May 2004 (doi: 10.1074/jbc.M400642200.)

Download references

Author information

Affiliations

  1. Swedish Institute for Infectious Disease Control, Solna, the Microbiology and Tumor Biology Center, and the Centre for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden. birgitta.henriques@smi.ki.se

    • Birgitta Henriques Normark
    • , Staffan Normark
    •  & Anna Norrby-Teglund

Authors

  1. Search for Birgitta Henriques Normark in:

  2. Search for Staffan Normark in:

  3. Search for Anna Norrby-Teglund in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm0804-780

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing