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Redistricting the retroviral restriction factors

Nature Medicine volume 10, pages 778–780 (2004)Cite this article

The cytoplasmic protein TRIM5α blocks the growth of HIV in rhesus monkey cells. Three studies now show that TRIM5α is an even more broadly active inhibitor. It impairs the growth of highly divergent retroviruses in human and other primate cells and fully accounts for many previously described antiretroviral activities.

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Figure 1: TRIM5α in retroviral restriction.

Erin Boyle

References

  1. Stremlau, M. et al. Nature 427, 848–853 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Hatziioannou, T., Perez-Caballero, D., Yang, A., Cowan, S. & Bieniasz, P.D. Proc. Natl. Acad. Sci. USA. Published online 12 July 2004 (doi: 10.1073/pnas.0402361101.)

  3. Keckesova, Z., Ylinen, L.M.J. & Towers, G. Proc. Natl. Acad. Sci. USA. Published online 12 July 2004 (doi: 10.1073/pnas.0402474101.)

  4. Yap, M.W., Nisole, S., Lynch, C. & Stoye, J.P. Proc. Natl. Acad. Sci. USA. Published online 12 July 2004 (doi: 10.1073/pnas.0402876101.)

  5. Towers, G. et al. Proc. Natl. Acad. Sci. USA 97, 12295–12299 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hofmann, W. et al. J. Virol. 73, 10020–10028 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Chelbi-Alix, M.K., Quignon, F., Pelicano, L., Koken, M.H. & de The, H. J. Virol. 72, 1043–1051 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Lilly, F. J. Natl. Cancer Inst. 45, 163–169 (1970).

    CAS  PubMed  Google Scholar 

  9. Hartley, J.W., Rowe, W.P. & Huebner, R.J. J. Virol. 5, 221–225 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Kozak, C.A. & Chakraborti, A. Virology 225, 300–305 (1996).

    Article  CAS  PubMed  Google Scholar 

  11. Best, S., Le Tissier, P., Towers, G. & Stoye, J.P. Nature 382, 826–829 (1996).

    Article  CAS  PubMed  Google Scholar 

  12. Sheehy, A.M., Gaddis, N.C., Choi, J.D. & Malim, M.H. Nature 418, 646–650 (2002).

    Article  CAS  PubMed  Google Scholar 

  13. Stopak, K., de Noronha, C., Yonemoto, W. & Greene, W.C. Mol. Cell 12, 591–601 (2003).

    Article  CAS  PubMed  Google Scholar 

  14. Marin, M., Rose, K.M., Kozak, S.L. & Kabat, D. Nat. Med. 9, 1398–1403 (2003).

    Article  CAS  PubMed  Google Scholar 

  15. Sheehy, A.M., Gaddis, N.C. & Malim, M.H. Nat. Med. 9 1404–1407 (2003).

    Article  CAS  PubMed  Google Scholar 

Download references

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  1. Gladstone Institute of Virology and Immunology, and University of California, San Francisco, San Francisco, 94141, California, USA

    Warner C Greene

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  1. Warner C Greene
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Greene, W. Redistricting the retroviral restriction factors. Nat Med 10, 778–780 (2004). https://doi.org/10.1038/nm0804-778

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