Commentary | Published:

Urgently needed: a filter for the HIV-1 vaccine pipeline

Nature Medicine volume 10, pages 769771 (2004) | Download Citation

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Research groups worldwide are trying to make immunogens intended to elicit neutralizing antibody responses as part of a prophylactic vaccine to counter the spread of HIV-1. The relative merits of different designs can only be gauged properly through comparative studies, and particularly by evaluating human or animal antisera under identical, or comparable, conditions. Hence there is a need for assay standardization and for the creation of a centralized testing facility that could distribute consensus protocols and reagents.

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Acknowledgements

We thank J. Mascola, D. Montefiori and R. Wyatt for helpful comments. Research on HIV-1 vaccine projects in the authors' laboratories is supported by the US National Institutes of Health and by the International AIDS Vaccine Initiative.

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Affiliations

  1. John P. Moore is in the Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA. jpm2003@med.cornell.edu

    • John P Moore
  2. Dennis R. Burton is in the Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA. burton@scripps.edu

    • Dennis R Burton

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DOI

https://doi.org/10.1038/nm0804-769

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