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Protect the killer: CTLs need defenses against the tumor

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Evasion of the immune system is an all too common feature of cancer. A new study suggests one evasion mechanism: induction of T-cell apoptosis through B7-H1, a molecule expressed on the surface of many tumor cells (pages 793–800).

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Figure 1: Consequences of B7-H1 engagement.

Renee Lucas