Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Rats lighten up with MCH antagonist

A new anti-obesity drug that targets brain pathways controlling energy balance in rats also works against depression and anxiety (pages 825–830).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Neurocircuitry involved in energy homeostasis.

References

  1. Kopelman, P.G. Obesity as a medical problem. Nature 404, 635–643 (2000).

    Article  CAS  Google Scholar 

  2. Schwartz, M.W., Woods, S.C., Porte, D. Jr, Seeley, R.J. & Baskin, D.G. Central nervous system control of food intake. Nature 404, 661–671 (2000).

    Article  CAS  Google Scholar 

  3. Borowsky, B. et al. Antidepressant, anxiolytic and anorectic effects of a Melanin-concentrating hormone-1 receptor antagonist. Nature Med. 8, 825–830 (2002).

    Article  CAS  Google Scholar 

  4. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994).

    Article  CAS  Google Scholar 

  5. Barsh, G.S., Farooqi, I.S. & O'Rahilly S. Genetics of body-weight regulation. Nature. 404, 644–651 (2000).

    Article  CAS  Google Scholar 

  6. Porte, D. Jr et al. Obesity, diabetes and the central nervous system. Diabetologia 41, 863–881 (1998).

    Article  CAS  Google Scholar 

  7. Obici, S., Feng, Z., Karkanias, G., Baskin, D.G. & Rossetti, L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nature Neurosci. 6, 566–572 (2002).

    Article  Google Scholar 

  8. Flier, J.S. & Maratos-Flier, E. Obesity and the hypothalamus: Novel peptides for new pathways. Cell 92, 437–440 (1998).

    Article  CAS  Google Scholar 

  9. Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J. & Cone, R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165–168 (1997).

    Article  CAS  Google Scholar 

  10. Nakazato, M. et al. A role for ghrelin in the central regulation of feeding. Nature 409, 194–198 (2001).

    Article  CAS  Google Scholar 

  11. Cummings, D.E. et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N. Engl. J. Med. 346, 1623–1630 (2002).

    Article  Google Scholar 

  12. Elias C.F. et al. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J. Comp. Neurol. 402, 442–459 (1998).

    Article  CAS  Google Scholar 

  13. Hanada, R. et al. Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related protein/melanocortin-4 receptor system. Biochem. Biophys. Res. Commun. 268 88–91 (2000).

    Article  CAS  Google Scholar 

  14. Shimada, M., Tritos, N.A., Lowell, B.B., Flier, J.S. & Maratos-Flier, E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396, 670–674 (1998).

    Article  CAS  Google Scholar 

  15. Barsh, G. & Schwartz, M.W. Genetic approaches to studying energy balance: Perception and integration. Nature. Rev. Genet. (in the press).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schwartz, M., Gelling, R. Rats lighten up with MCH antagonist. Nat Med 8, 779–781 (2002). https://doi.org/10.1038/nm0802-779

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0802-779

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing