Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overall reactivity of the immune system, the specific antigen and its presentation, and the target issue.
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This work was supported by NIH grants AI-17134, AI-18785, AI-22295 and AR-37070.
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Marrack, P., Kappler, J. & Kotzin, B. Autoimmune disease: why and where it occurs. Nat Med 7, 899–905 (2001). https://doi.org/10.1038/90935
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