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A Nod toward understanding Crohn's pathology

Nature Medicine volume 17, pages 785–787 (2011)Cite this article

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Despite intensive study, the mechanisms of pathogenesis in inflammatory bowel diseases (IBDs) remain poorly understood. An innate T helper type 17 (TH17) response that requires nucleotide oligomerization domain (Nod)-like receptors and is primed by commensal bacteria is now shown to be crucial for controlling intestinal bacterial pathogens in a mouse model (pages 837–844). Thus, dysregulation of this protective immune response may be important in IBD development.

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Figure 1: Early 'innate' mucosal TH17 response versus late reactions to acute enterobacterial infection.

References

  1. Girardin, S.E. et al. EMBO Rep. 2, 736–742 (2001).

    Google Scholar 

  2. Ogura, Y. et al. Nature 411, 603–606 (2001).

    Google Scholar 

  3. Hugot, J.P. et al. Nature 411, 599–603 (2001).

    Google Scholar 

  4. Franke, A. et al. Nat. Genet. 42, 1118–1125 (2010).

    Google Scholar 

  5. Geddes, K. et al. Nat. Med. 17, 837–844 (2011).

    Google Scholar 

  6. Willing, B.P. et al. Gastroenterology. 139, 1844–1854.e1 (2010).

    Google Scholar 

  7. Petnicki-Ocwieja, T. et al. Proc. Natl. Acad. Sci. USA 106, 15813–15818 (2009).

    Google Scholar 

  8. Barreau, F. et al. Gut 59, 207–217 (2010).

    Google Scholar 

  9. Watanabe, T. et al. J. Clin. Invest. 118, 545–559 (2008).

    Google Scholar 

  10. Kim, Y.G. et al. Immunity 34, 769–780 (2011).

    Google Scholar 

  11. Gaboriau-Routhiau, V. et al. Immunity 31, 677–689 (2009).

    Google Scholar 

  12. Ivanov, I.I. et al. Cell 139, 485–498 (2009).

    Google Scholar 

  13. Lee, W.W. et al. Blood 115, 530–540 (2010).

    Google Scholar 

  14. Stecher, B. et al. PLoS Biol. 5, 2177–2189 (2007).

    Google Scholar 

  15. Rehman, A. et al. Gut published online, doi:gut.2010.216259 18 March (2011).

  16. Frank, D.N. et al. Inflamm. Bowel Dis. 17, 179–184 (2011).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Mathias Hornef and Christine Josenhans are at the Hannover Medical School, Institute of Medical Microbiology and Hospital Epidemiology, Hannover, Germany.,

    Mathias Hornef & Christine Josenhans

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  1. Mathias Hornef
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  2. Christine Josenhans
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Correspondence to Christine Josenhans.

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The authors declare no competing financial interests.

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Hornef, M., Josenhans, C. A Nod toward understanding Crohn's pathology. Nat Med 17, 785–787 (2011). https://doi.org/10.1038/nm0711-785

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