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The brain splits obesity and hypertension

Nature Medicine volume 17, pages 782–783 (2011)Cite this article

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Obesity and high blood pressure are commonly associated. A study in mice now shows that hypothalamic inflammatory pathways may be the link connecting these two disorders and a potential target to uncouple obesity-related hypertension from weight gain (pages 883–887).

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Figure 1: Overview of the suggested pathways by which obesity and hypertension are linked.

Mary Lou Quillen

References

  1. Hall, J.E. et al. J. Biol. Chem. 285, 17271–17276 (2010).

    Article  CAS  Google Scholar 

  2. Könner, A.C., Klockener, T. & Bruning, J.C. Physiol. Behav. 97, 632–638 (2009).

    Article  Google Scholar 

  3. Lakoski, S.G. et al. J. Hum. Hypertens. 25, 73–79 (2011).

    Article  CAS  Google Scholar 

  4. Purkayastha, S., Zhang, G. & Cai, D. Nat. Med. 17, 883–887 (2011)

    Article  CAS  Google Scholar 

  5. Zhang, X. et al. Cell 135, 61–73 (2008).

    Article  CAS  Google Scholar 

  6. Ni, X.-P. et al. J. Clin. Invest. 111, 1251–1258 (2003).

    Article  CAS  Google Scholar 

  7. Tallam, L.S. et al. Hypertension 46, 326–332 (2005).

    Article  CAS  Google Scholar 

  8. Humphreys, M.H., Ni, X.-P. & Pearce, D. Eur. J. Pharmacol. 660, 43–52 (2011).

    Article  CAS  Google Scholar 

  9. Mehta, S. & Farmer, J.A. Curr. Atheroscler. Rep. 9, 134–138 (2007).

    Article  CAS  Google Scholar 

  10. Rahmouni, K. Curr. Hypertens. Rev. 6, 104–209 (2010).

    Article  CAS  Google Scholar 

  11. Prior, L.J. et al. Hypertension 55, 862–868 (2010).

    Article  CAS  Google Scholar 

  12. Jang, P.-G. et al. J. Biol. Chem. 285, 9706–9715 (2010).

    Article  CAS  Google Scholar 

  13. Harlan, S.M. et al. Circ. Res. 108, 808–812 (2011).

    Article  CAS  Google Scholar 

  14. Hotamisligil, G.S., Shargill, N.S. & Spiegelman, B.M. Science 259, 87–91 (1993).

    Article  CAS  Google Scholar 

Download references

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  1. Michael H. Humphreys is in the Division of Nephrology, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA.,

    Michael H Humphreys

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  1. Michael H Humphreys
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Correspondence to Michael H Humphreys.

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The author declares no competing financial interests.

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Humphreys, M. The brain splits obesity and hypertension. Nat Med 17, 782–783 (2011). https://doi.org/10.1038/nm0711-782

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