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Pregnancy hormones boost beta cells via serotonin

Pregnancy increases the demand for insulin by various tissues in the body, a condition that can lead to gestational diabetes. To shield against this condition, insulin-producing beta cells proliferate in a process now shown to involve the local production of serotonin in response to lactogenic hormones (pages 804–808).

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Figure 1: Insulin-producing beta cells expand during pregnancy through pathways involving lactogenic and serotonergic signaling.

Katie Vicari


  1. Sorenson, R.L. & Brelje, T.C. Horm. Metab. Res. 29, 301–307 (1997).

    Article  CAS  Google Scholar 

  2. Rieck, S. & Kaestner, K.H. Trends Endocrinol. Metab. 21, 151–158 (2010).

    Article  CAS  Google Scholar 

  3. Freemark, M. et al. Endocrinology 143, 1378–1385 (2002).

    Article  CAS  Google Scholar 

  4. Vasavada, R.C. et al. J. Biol. Chem. 275, 15399–15406 (2000).

    Article  CAS  Google Scholar 

  5. Zhang, H. et al. Diabetes 59, 143–152 (2010).

    Article  Google Scholar 

  6. Kim, H. et al. Nat. Med. 16, 804–808 (2010).

    Article  CAS  Google Scholar 

  7. Paulmann, N. et al. PLoS Biol. 7, e1000229 (2009).

    Article  Google Scholar 

  8. Matsuda, M. et al. Dev. Cell 6, 193–203 (2004).

    Article  CAS  Google Scholar 

  9. Lesurtel, M. et al. Science 312, 104–107 (2006).

    Article  CAS  Google Scholar 

  10. Collet, C. et al. FASEB J. 22, 418–427 (2008).

    Article  CAS  Google Scholar 

  11. Yadav, V.K. et al. Cell 135, 825–837 (2008).

    Article  CAS  Google Scholar 

  12. Picard, F. et al. Proc. Natl. Acad. Sci. USA 99, 15644–15648 (2002).

    Article  CAS  Google Scholar 

  13. Karnik, S.K. et al. Science 318, 806–809 (2007).

    Article  CAS  Google Scholar 

  14. Pinney, S.E. & Simmons, R.A. Trends Endocrinol. Metab. 21, 223–229 (2010).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Anil Bhushan.

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Georgia, S., Bhushan, A. Pregnancy hormones boost beta cells via serotonin. Nat Med 16, 756–757 (2010).

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