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RAF translocations expand cancer targets

Nature Medicine volume 16, pages 749–750 (2010)Cite this article

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Chromosomal translocations can promote cancers by eliciting the expression of fusion genes with oncogenic activity. The identification of translocations affecting RAF genes in prostate and gastric cancers and melanoma provides compelling evidence for the key role of RAF signaling in a subset of these cancers and suggests possible new avenues for personalized cancer therapy (pages 793–798).

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Figure 1: RAF fusion genes in prostate and gastric cancer and melanoma.

Katie Vicari

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  1. Martin McMahon is Efim Guzik Distinguished Professor of Cancer Biology at the Helen Diller Family Comprehensive Cancer Center, University of California–San Francisco, California, USA.,

    Martin McMahon

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  1. Martin McMahon
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Correspondence to Martin McMahon.

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McMahon, M. RAF translocations expand cancer targets. Nat Med 16, 749–750 (2010). https://doi.org/10.1038/nm0710-749

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