Targeting lymphotoxin depletes pathogenic T cells

A monoclonal antibody directed against lymphotoxin-α (LT-α) expressed by pathogenic T cells can prompt the clearance of these cells from the body (pages 766–773). The findings bring us one step closer to targeting only the cell populations that cause harm in autoimmune diseases while leaving beneficial arms of the immune system largely intact.

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Figure 1: Schematic of binding of LT-α–specific antibody (anti–LT-α).

Katie Vicari

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Correspondence to Rachel R. Caspi.

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Hansen, A., Caspi, R. Targeting lymphotoxin depletes pathogenic T cells. Nat Med 15, 732–733 (2009). https://doi.org/10.1038/nm0709-732

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