Targeting lymphotoxin depletes pathogenic T cells

A monoclonal antibody directed against lymphotoxin-α (LT-α) expressed by pathogenic T cells can prompt the clearance of these cells from the body (pages 766–773). The findings bring us one step closer to targeting only the cell populations that cause harm in autoimmune diseases while leaving beneficial arms of the immune system largely intact.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Schematic of binding of LT-α–specific antibody (anti–LT-α).

Katie Vicari


  1. 1

    Caspi, R.R. Nat. Rev. Immunol. 8, 970–976 (2008).

  2. 2

    Chiang, E. et al. Nat. Med. 15, 766–773 (2009).

  3. 3

    O'Garra, A. & Arai, N. Trends Cell Biol. 10, 542–550 (2000).

  4. 4

    Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V.K. Annu. Rev. Immunol. 27, 485–517 (2009).

  5. 5

    Abbas, A.R. Genes Immun. 6, 319–331 (2005).

  6. 6

    Sakaguchi, S., Yamaguchi, T., Nomura, T. & Ono, M. Cell 133, 775–787 (2008).

  7. 7

    Shevach, E.M. Immunity 30, 636–645 (2009).

Download references

Author information

Correspondence to Rachel R. Caspi.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hansen, A., Caspi, R. Targeting lymphotoxin depletes pathogenic T cells. Nat Med 15, 732–733 (2009).

Download citation

Further reading