Tumor immunotherapy: making an immortal army

Manipulation of cell renewal pathways creates T memory stem cells that can generate a sustained and targeted immune response. These findings have broad implications for vaccine development and immunotherapy (pages 808–813).

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Figure 1: Same pathway, different outcomes? During hematopoiesis in the bone marrow, the Wnt–β-catenin pathway limits the proliferation and differentiation of hematopoietic stem cells (HSCs) so that division can regenerate HSCs in addition to the multipotent stem cells (MSCs) that give rise to lymphoid progenitor cells (LPCs) and myeloid progenitor stem cells (MPCs).

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Correspondence to Stephen P. Schoenberger.

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Koehn, B., Schoenberger, S. Tumor immunotherapy: making an immortal army. Nat Med 15, 731–732 (2009). https://doi.org/10.1038/nm0709-731

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