Coupling bone degradation to formation

To maintain skeletal integrity and prevent fractures, degradation and rebuilding of bone must occur in synchrony. Transforming growth factor-β1 is now found to coordinate this restructuring process: the molecule is released during bone degradation and stimulates bone rebuilding (pages 757–765).

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Figure 1: Premature TGF-β1 activation in Camurati-Engelmann disease (CED) leads to haphazard bone formation and poor bone quality.

Katie Vicari

References

  1. 1

    Iqbal, J. & Zaidi, M. Biochem. Biophys. Res. Commun. 328, 751–755 (2005).

  2. 2

    Zaidi, M. Nat. Med. 13, 791–801 (2007).

  3. 3

    Tang, Y. et al. Nat. Med. 15, 757–765 (2009).

  4. 4

    Bonewald, L.F. & Mundy, G.R. Connect. Tissue Res. 23, 201–208 (1989).

  5. 5

    Oreffo, R.O., Mundy, G.R., Seyedin, S.M. & Bonewald, L.F. Biochem. Biophys. Res. Commun. 158, 817–823 (1989).

  6. 6

    Kakonen, S.M. et al. J. Biol. Chem. 277, 24571–24578 (2002).

  7. 7

    Erlebacher, A., Filvaroff, E.H., Ye, J.Q. & Derynck, R. Mol. Biol. Cell 9, 1903–1918 (1998).

  8. 8

    Filvaroff, E. et al. Development 126, 4267–4279 (1999).

  9. 9

    Lucas, P.A. Bone 10, 459–463 (1989).

  10. 10

    Gupta, S. & Cheikh, I.E. Endocr. Pract. 11, 399–407 (2005).

  11. 11

    Kurihara, N. et al. J. Bone Miner. Res. 21 Suppl 2, 55–57 (2006).

  12. 12

    Mohammad, K.S. et al. PLoS One 4, e5275 (2009).

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Correspondence to Mone Zaidi.

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Iqbal, J., Sun, L. & Zaidi, M. Coupling bone degradation to formation. Nat Med 15, 729–731 (2009). https://doi.org/10.1038/nm0709-729

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