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Coupling bone degradation to formation

Nature Medicine volume 15, pages 729–731 (2009)Cite this article

To maintain skeletal integrity and prevent fractures, degradation and rebuilding of bone must occur in synchrony. Transforming growth factor-β1 is now found to coordinate this restructuring process: the molecule is released during bone degradation and stimulates bone rebuilding (pages 757–765).

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Figure 1: Premature TGF-β1 activation in Camurati-Engelmann disease (CED) leads to haphazard bone formation and poor bone quality.

Katie Vicari

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Authors and Affiliations

  1. The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, USA

    Jameel Iqbal, Li Sun & Mone Zaidi

Authors
  1. Jameel Iqbal
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  2. Li Sun
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  3. Mone Zaidi
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Correspondence to Mone Zaidi.

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Iqbal, J., Sun, L. & Zaidi, M. Coupling bone degradation to formation. Nat Med 15, 729–731 (2009). https://doi.org/10.1038/nm0709-729

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