Imatinib buys time for brain after stroke

The most effective drug to treat acute ischemic stroke, tissue plasminogen activator (tPA), must be applied within three hours after symptom onset because of the risk of hemorrhage and other complications such as neurotoxicity. The anticancer drug imatinib (Gleevec) may help overcome these limitations by counteracting the ability of tPA to increase the permeability of the blood-brain barrier (pages 731–737).

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Figure 1: Delayed tPA treatment in thrombembolic stroke.

Katie Ris-Vicari

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Rieckmann, P. Imatinib buys time for brain after stroke. Nat Med 14, 712–713 (2008). https://doi.org/10.1038/nm0708-712

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