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Phosphoinositides' link to neurodegeneration

Nature Medicine volume 13, pages 784–786 (2007)Cite this article

Mutations in the phosphoinositide metabolism gene FIG4 disrupt the endosomal pathway, leading to neurodegeneration and a newly identified variant of Charcot-Marie-Tooth disorder.

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Figure 1: Phosphoinositide composition of membranes along the endocytic pathway, including the localization of phosphatidylinositol-3-phosphate (PI3P) and the putative localization of phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2).

Katie Ris

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Authors and Affiliations

  1. Laura Volpicelli-Daley and Pietro De Camilli are in the Department of Cell Biology, Howard Hughes Medical Institute and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06510, USA. pietro.decamilli@yale.edu,

    Laura Volpicelli-Daley & Pietro De Camilli

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  1. Laura Volpicelli-Daley
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  2. Pietro De Camilli
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Volpicelli-Daley, L., De Camilli, P. Phosphoinositides' link to neurodegeneration. Nat Med 13, 784–786 (2007). https://doi.org/10.1038/nm0707-784

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