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IL-1α responds to necrotic cell death

Necrosis induces inflammation, but how necrotic cells signal to immune cells was poorly understood. New work by Chen et al. shows that IL-1α acts as a mediator, translating a signal from the necrotic cells to induce the recruitment of immune cells to the site of injury (pages 851–856).

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Figure 1: Necrotic cells stimulate neutrophilic inflammation through IL-1α.

Katie Ris

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Elkon, K. IL-1α responds to necrotic cell death. Nat Med 13, 778–780 (2007). https://doi.org/10.1038/nm0707-778

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