Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IL-1α responds to necrotic cell death

Nature Medicine volume 13, pages 778–780 (2007)Cite this article

Necrosis induces inflammation, but how necrotic cells signal to immune cells was poorly understood. New work by Chen et al. shows that IL-1α acts as a mediator, translating a signal from the necrotic cells to induce the recruitment of immune cells to the site of injury (pages 851–856).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Necrotic cells stimulate neutrophilic inflammation through IL-1α.

Katie Ris

References

  1. Galluzzi, L. et al. Cell Death Differ. advance online publication, 13 April 2007 (doi:10.1038/sj.cdd.4402148).

    Article  CAS  Google Scholar 

  2. Festjens, N., Vanden Berghe, T. & Vandenabeele, P. Biochim. Biophys. Acta 1757, 1371–1387 (2006).

    Article  CAS  Google Scholar 

  3. Chen, C.-J. et al. Nat. Med. 13, 851–856 (2007).

    Article  CAS  Google Scholar 

  4. Tian, J. et al. Nat. Immunol. 8, 487–496 (2007).

    Article  CAS  Google Scholar 

  5. Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Nature. 440, 237–241 (2006).

    Article  CAS  Google Scholar 

  6. Shi, Y., Evans, J.E. & Rock, K.L. Nature. 425, 516–521 (2003).

    Article  CAS  Google Scholar 

  7. Dinarello, C.A. in Fundamental Immunology (ed. Paul, W.E.) 775–799 (Lippincott Williams & Wilkins, Philadelphia, 2003).

    Google Scholar 

  8. Brody, D.T. & Durum, S.K. J. Immunol. 143, 1183–1187 (1989).

    CAS  PubMed  Google Scholar 

  9. Dinarello, C.A. Curr. Opin. Pharmacol. 4, 378–385 (2004).

    Article  CAS  Google Scholar 

  10. Miller, L.S. et al. Immunity 24, 79–91 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Keith B. Elkon is in the Departments of Medicine and Immunology, University of Washington, 1959 NE Pacific Avenue, Box 356428, Seattle, Washington 98195, USA. elkon@u.washington.edu,

    Keith B Elkon

Authors
  1. Keith B Elkon
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Elkon, K. IL-1α responds to necrotic cell death. Nat Med 13, 778–780 (2007). https://doi.org/10.1038/nm0707-778

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0707-778

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing