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A new link to airway obstruction in asthma

The factors that regulate airway goblet cell metaplasia and mucus secretion are essential to understanding how airway obstruction occurs in asthma. In this issue, Xiang et al. demonstrate the existence of an airway epithelial, extraneuronal GABAergic signaling system that promotes mucus overproduction during allergic airway inflammation (pages 862–867).

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Figure 1: Regulation of goblet cell metaplasia during allergic airway inflammation.

Katie Ris

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Corry, D., Kheradmand, F. A new link to airway obstruction in asthma. Nat Med 13, 777–778 (2007). https://doi.org/10.1038/nm0707-777

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