Aβ generation requires γ-secretase activity. Inhibition of γ-secretase may now be easier due to the recent identification of the four proteins that make up the γ-secretase complex.
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Kim Caesar
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Takashima, A., Shimojo, M. & Wolozin, B. The players on the γ-secretase team. Nat Med 12, 766–767 (2006). https://doi.org/10.1038/nm0706-766
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DOI: https://doi.org/10.1038/nm0706-766
