Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Teasing out the tangles

Tau aggregates into insoluble tangles in the brains of individuals with Alzheimer disease. Recent work suggests that these tangles do not cause the cognitive decline that typifies the disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Axonal transport proceeds along microtubule tracks (blue), covered by microtubule-associated proteins (MAPs) such as tau (tan), which are involved in correct spacing and stabilization of the tracks (lower panel).

Katie Ris


  1. Ramsden, M. et al. J. Neurosci. 25, 10637–10647 (2005).

    Article  CAS  Google Scholar 

  2. Santacruz, K. et al. Science 309, 476–481 (2005).

    Article  CAS  Google Scholar 

  3. Spires, T.L. et al. Am. J. Pathol. 168, 1598–1607 (2006).

    Article  CAS  Google Scholar 

  4. Caughey, B. & Lansbury, P.T. Annu. Rev. Neurosci. 26, 267–298 (2003).

    Article  CAS  Google Scholar 

  5. Gotz, J. et al. Int. J. Dev. Neurosci. 22, 453–465 (2004).

    Article  Google Scholar 

  6. McLean, C.A. et al. Ann. Neurol. 46, 860–866 (1999).

    Article  CAS  Google Scholar 

  7. Lesne, S. et al. Nature 440, 352–357 (2006).

    Article  CAS  Google Scholar 

  8. Kril, J.J. et al. Acta Neuropathol. (Berl.) 103, 370–376 (2002).

    Article  Google Scholar 

  9. Arrasate, M. et al. Nature 431, 805–810 (2004).

    Article  CAS  Google Scholar 

  10. Ebneth, A. et al. J. Cell Biol. 143, 777–794 (1998).

    Article  CAS  Google Scholar 

  11. Mandelkow, E.M. et al. J. Cell Biol. 167, 99–110 (2004).

    Article  CAS  Google Scholar 

  12. Terry, R.D. J. Neuropathol. Exp. Neurol. 55, 1023–1025 (1996).

    Article  CAS  Google Scholar 

  13. Praprotnik, D. et al. Acta Neuropathol. (Berl.) 91, 226–235 (1996).

    Article  CAS  Google Scholar 

  14. Gotz, J. et al. J. Neurochem. (in the press).

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Kins, S., Beyreuther, K. Teasing out the tangles. Nat Med 12, 764–765 (2006).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing