Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The ups and downs of Aβ

How do Aβ levels increase in individuals with Alzheimer disease? Recent work suggests that some forms of neuronal activity can drive Aβ accumulation in the brain.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Katie Ris


  1. Cirrito, J.R. et al. Neuron 48, 913–922 (2005).

    Article  CAS  Google Scholar 

  2. Kamenetz, F. et al. Neuron 37, 925–937 (2003).

    Article  CAS  Google Scholar 

  3. Lazarov, O., Lee, M., Peterson, D.A. & Sisodia, S.S. J. Neurosci. 22, 9785–9793 (2002).

    Article  CAS  Google Scholar 

  4. Sheng, J.G., Price, D.L. & Koliatsos, V.E. J. Neurosci. 22, 9794–9749 (2002).

    Article  CAS  Google Scholar 

  5. Buckner, R.L. et al. J. Neurosci. 25, 7709–7717 (2005).

    Article  CAS  Google Scholar 

  6. Kim, D.Y., Ingano, L.A., Carey, B.W., Pettingell, W.H. & Kovacs, D.M. J. Biol. Chem. 280, 23251–23261 (2005).

    Article  CAS  Google Scholar 

  7. Nitsch, R.M., Farber, S.A., Growdon, J.H. & Wurtman, R.J. Proc. Natl. Acad. Sci. USA 90, 5191–5193 (1993).

    Article  CAS  Google Scholar 

  8. Selkoe, D.J. & Schenk, D. in Annual Review of Pharmacology and Toxicology Vol 43 (eds. Cho, A.K., Blaschke, T.F., Insel, P.A. & Loh, H.H.) 545–584 (Annual Reviews, Palo Alto, California, 2003).

    Google Scholar 

  9. Bateman, R. et al. Nat. Med. 12, 856–861 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Selkoe, D. The ups and downs of Aβ. Nat Med 12, 758–759 (2006).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing