Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Putting the heat on febrile seizures

Young children are particularly susceptible to seizures induced by high fever. Experiments in rats suggest that changes in brain pH might be to blame (pages 817823).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The sequence of events leading to seizures after fever in rat pups.

Kim Caesar


  1. Niedermeyer, E. The Epilepsies. Diagnosis and Management. (Urban & Schwarzenberg, Baltimore, 1990).

    Google Scholar 

  2. Schuchmann, S. et al. Nat. Med. 12, 817–823 (2006).

    Article  CAS  Google Scholar 

  3. Chesler, M. Physiol. Rev. 83, 1183–1221 (2003).

    Article  CAS  Google Scholar 

  4. Aram, J.A. & Lodge, D. Neurosci. Lett. 83, 345–350 (1987).

    Article  CAS  Google Scholar 

  5. de Curtis, M., Manfridi, A. & Biella, G. J. Neurosci. 18, 7543–7551 (1998).

    Article  CAS  Google Scholar 

  6. Putnam, R.W. et al. Respir. Physiol. Neurobiol. 149, 165–179 (2005).

    Article  Google Scholar 

  7. Dube, C. et al. Ann. Neurol. 47, 336–344 (2000).

    Article  CAS  Google Scholar 

  8. Chen, K. et al. Nat. Med. 7, 331–337 (2001).

    Article  CAS  Google Scholar 

  9. Chen, K. et al. Neuron 39, 599–611 (2003).

    Article  CAS  Google Scholar 

  10. Gottfried, J.A. & Chesler, M. J. Physiol. 478, 373–378 (1994).

    Article  CAS  Google Scholar 

  11. Velíšek, L. et al. Exp. Brain Res. 101, 44–52 (1994).

    Article  Google Scholar 

  12. Berg, A.T. & Shinnar, S. Epilepsia 37, 126–133 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Tapia, R. Putting the heat on febrile seizures. Nat Med 12, 729–730 (2006).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing