Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Glial cell line–derived neurotrophic factor induces neuronal sprouting in human brain

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: UPDRS-III scores, 18F-dopa uptake and neuropathological findings.


  1. Patel, N.K. et al. Ann. Neurol. 57, 298–302 (2005).

    Article  CAS  Google Scholar 

  2. Gill, S.S. et al. Nat. Med. 9, 589–595 (2003).

    Article  CAS  Google Scholar 

  3. Langston, J.W. et al. Mov. Disord. 7, 2–13 (1992).

    Article  CAS  Google Scholar 

  4. Patel, N.K. et al. Mov. Disord. 17 Suppl 9, 727 (2004).

    Google Scholar 

  5. Chalmers, K., Wilcock, G.K. & Love, S. Neuropathol. Appl. Neurobiol. 29, 231–238 (2003).

    Article  CAS  Google Scholar 

  6. Opacka-Juffry, J. et al. Neuroreport 7, 348–352 (1995).

    CAS  PubMed  Google Scholar 

  7. Tomac, A. et al. Nature 373, 335–339 (1995).

    Article  CAS  Google Scholar 

  8. Date, I., Aoi, M., Tomita, S., Collins, F. & Ohmoto, T. Neuroreport 9, 2365–2369 (1998).

    Article  CAS  Google Scholar 

  9. Kirik, D., Georgievska, B. & Bjorklund, A. Nat. Neurosci. 7, 105–110 (2004).

    Article  CAS  Google Scholar 

Download references


We thank C. Redman, R. Quilty, T. McLaren, M. Jennings and R. Barber for technical assistance. Amgen, Inc. supplied the GDNF for this trial.

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Love, S., Plaha, P., Patel, N. et al. Glial cell line–derived neurotrophic factor induces neuronal sprouting in human brain. Nat Med 11, 703–704 (2005).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing